Effects of pigment epithelium-derived factor on the expression of vascular endothelial growth factor and reactive oxygen species in the human mesangial cells
10.3760/cma.j.issn.1000-6699.2010.12.015
- VernacularTitle:PEDF对人肾小球系膜细胞VEGF表达及活性氧簇产生的影响
- Author:
Huiqin LI
;
Jing LI
;
Tuohua MA
- Publication Type:Journal Article
- Keywords:
Pigment epithelium derived factor;
Vascular endothelial growth factor;
Oxidative stress;
Diabetic nephropathy;
Human mesangial cells
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(12):1067-1069
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of vascular endothelial growth factor (VEGF)and the levels of reactive oxygen species (ROS)in human mesangial cells cultured in high glucose and being intervened by pigment epithelium-derived factor (PEDF). The results showed that with increased glucose concentration, the expressions of VEGF and ROS generation also gradually increased and PEDF significantly downregulated VEGF expression and ROS generation in a dose-dependent manner. PEDF may delay the diabetic nephropathy progress by improving vascular permeability and inhibiting oxidative stress.
