Pharmacodynamics of different local anestheties administered intrathecally for elderly patients undergoing transurethral resection of the prostate
10.3760/cma.j.issn.0254-1416.2010.09.037
- VernacularTitle:经尿道前列腺电切术老年患者鞘内注射不同局麻药的药效学
- Author:
Bin ZHENG
;
Shouzhang SHE
;
Wenting FU
;
Yanru ZENG
;
Yanyun WU
;
Lixin XU
;
Xuebing XU
- Publication Type:Journal Article
- Keywords:
Bupivacaine;
Amides;
Dose-response relationship,drug;
Injections,spinal;
Transurethral resection of prostate
- From:
Chinese Journal of Anesthesiology
2010;30(9):1139-1141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacodynamics of different local anesthetics administered intrathecally for elderly patients undergoing transurethral resection of the prostate (TURP). Methods Ninety ASA Ⅰ - Ⅲ elderly patients, aged 69-82 yr, with body mass index less than 30 kg/m2 , undergoing TURP under combined spinal-epidural anesthesia, were randomly divided into 3 groups ( n = 30 each): levobupivacaine group (group L), ropivacaine group (group R) and bupivacaine group (group B). Group L, R and B received intrathecai (IT) 0.5 % levobupivacaine, 0.5 % ropivacaine and 0.5 % bupivacaine respectively. The initial dose was 7,10 and 6 mg in group L, R and B respectively. The ratio of two successive doses was 0.9. If the upper sensory block reached T10 within the 20 min after IT injection, the IT analgesia was considered to be effective. The median effective dose (EDs0) and 95 % confidence interval (95 % CI) were calculated by Dixon. Results The ED50 and 95% CI of levobupivacaine, ropivacaine and bupivacaine were 6.781 (95% CI 6.561-7.024) mg, 9.135 (95%CI8.670-9.616) mg and 5.170 (95% CI 5.012-5.333) ng respectively. The relative potency ratio between levobupivacaine, ropivacaine and bupivacaine is 0.76∶0.57∶1.00. ConclusionThe relative potency ratio be tween levobupivacaine, ropivacaine and bupivacaine is 0.76∶0.57∶1.00.
