A screen for genetic loci associated with bipolar disorder on chromosome 4

VernacularTitle:山东省双相情感障碍患者4号染色体基因扫描的初步研究
Author: Meng LUAN ; Jian TANG ; Peng ZHOU ; Xuerun CHANG ; Yuanxun WANG ; Shulin YANG ; Xing CHEN ; Wenmin LIU ; Wentian FAN ; Gang CHEN
Publication Type:Journal Article
Keywords: Bipolar disorder; Chromosome; Microsatellite; Gene; DNA pooling
From: Chinese Journal of Behavioral Medicine and Brain Science 2010;19(11):961-963
CountryChina
Language:Chinese
Abstract: Objective To find out association mapping of loci related to bipolar disorder on chromosome 4 with microsatellite markers in DNA pooling samples from bipolar disorder cases and normal controls in Shandong province. Methods A total of 22 microsatellite markers on chromosome 4 spaced at approximately 10 cM were selected and two separated DNA pooling samples consisting of 104 bipolar disorder cases and 1000 normal controls were genotyped respectively. Statistic analysis was performed by Chi-square method with CLUMP software to compare the difference in the ratio of each allele in these loci between the two pooling samples. Result Significant statistic differences were found at D4S1592 and D4S402 on chromosome 4 between cases and controls(P＜0.01 ).( D4S1592:x2 = 15.968, P=0.006; D4S402:x2 =31.553, P=0.002). Conclusion The loci of D4S1592 and D4S402 on chromosome 4 are found to be associated with bipolar disorder patients in Shandong province, further screening of the susceptibility genes around these loci is needed.