Mesenchymal stem cells reduce the irradiation induced lung injury

VernacularTitle:间充质干细胞治疗小鼠放射性肺损伤的病理学研究
Author: Ge SHEN ; Fang WANG ; Weijing ZHANG ; Bing LIU ; Shunzong YUAN ; Li WANG ; Yun SHAO
Publication Type:Journal Article
Keywords: Irradiation induced lung injury; Mesenchymal stem cells; Mouse bone; Mouse embryos dorsal aorta area
From: Chinese Journal of Radiological Medicine and Protection 2010;30(6):670-673
CountryChina
Language:Chinese
Abstract: Objective To evaluate the role of mesenchymal stem cells (MSCs) derived from mouse bone and embryo dorsal aorta(DA) area in the treatment of irradiation induced lung injury of mouse model. Methods The mice were divided into four groups as normal control group, irradiation group,bone MSCs treatment group and DA MSCs treatment group. Immunohistochemical Analysis of lung tissue was observed after 9 months of treatment. Results Fibrosis and alveolar infiltration were scored in each group. The score for fibrosis and alveolar is 0. 17 in normal control group, 2 in irradiation group, 1 in bone MSCs treat group and 1.38 in DA MSCs treat group. Conclusion The extent of irradiation Induced Lung Injury could be reduced thorough the treatment of MSCs derived from mouse bone and embryos dorsal aorta ( DA ) area.