Apelin-APJ system and angiogenesis
10.3760/cma.j.issn.1673-4165.2010.010.017
- VernacularTitle:Apelin-APJ系统与血管发生
- Author:
Guiying DENG
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Receptors,G-protein-coupled;
Neovascularizattion,physiologic;
Neovascularization,pathologic;
Endothelial growth factors;
Angiotensin-converting enzyme inhibitors
- From:
International Journal of Cerebrovascular Diseases
2010;18(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is one of the effective strategies for the treatment of ischemic cerebrovascular disease, and a variety of angiogenic factors and antiangiogenic factors involved in the process of regulation. Apelin is a newly discovered peptide, ari it is the endogenous ligand of G protein-coupled receptor APJ (Angiotensin Ⅱ Type 1 Receptor-Associated Protein). Apelin and APJ express widely in rat and human hearts and brains, etc. Apelin-APJ system has a role in promoting angiogenesis. It has an important significance in the treatment of ischemic diseases. This article review the mechanisms of action and advances in angiogenesis of apelin-APJ system.
