Organ allografts combined with hematopoietic stem cell transplantation and immunotolerance
10.3760/cma.j.issn.1007-8118.2010.12.025
- VernacularTitle:同种异体器官移植联合造血干细胞移植与免疫耐受
- Author:
Youguo DAI
;
Jinyan HUANG
- Publication Type:Journal Article
- Keywords:
Allograft;
Hematopoietic stem cell transplantation;
Immunotolerance
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(12):963-965
- CountryChina
- Language:Chinese
-
Abstract:
Our understanding of the immunological mechanisms of rejection has greatly improved over the past 10 years. The allografts have maintained long survival without immunosuppressive treatment in the several organ-transplant recipients combined with hematopoietic stem cell transplantation. The authors attributed the successful outcome to the cotransplantation of donor stem cells. The review will analyze firstly conditions of the recipients, and then review the theoretical basis and history regarding donor-specific tolerance of allograft, and it will also clarify that there is no direct link between the donor-specific transplantation tolerance and hematopoietic stem cell transplantation.
