Clinical and laboratory features of severe cases of hand, foot and mouth diseases in Wenzhou
10.3760/cma.j.issn.1674-2397.2010.06.005
- VernacularTitle:浙江省温州地区重症手足口病患儿临床和实验室特征分析
- Author:
Suhua LI
;
Jie CHEN
;
Hongjiao WANG
;
Junya CHEN
;
Zhiwei XU
;
Yiping CHEN
- Publication Type:Journal Article
- Keywords:
Hand,foot and mouth disease;
Enterovirus infections;
Clinical features;
Child
- From:
Chinese Journal of Clinical Infectious Diseases
2010;03(6):337-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and laboratory features of severe cases of hand,foot and mouth disease (HFMD) in Wenzhou, Zhejiang Province. Methods Clinical data of 107 children with HFMD, including 97 severe and 10 critical cases treated in Children' s Hospital Affiliated to Wenzhou Medical College during January and May 2010 were retrospectively analyzed. One hundred and fifty children with mild HFMD were also selected as the controls. Clinical features and laboratory results were compared between the two groups. Results Fever, rash and infection in central nervous system were observed in all patients with severe HFMD, and symptoms on respiratory, digestive and cardiovascular systems were more serious than those of mild HFMD cases. White blood cell counts (WBC) were higher in severe group than those in controls (t = 12.72, P ＜0.01). Hyperglycemia (9. 2 mmol/L) and abnormal troponin (0. 3 -9. 0 ng/mL) were presented in all the critical patients. Cerebrospinal fluid WBC counts were raised in 97 severe HFMD patients (98.5 × 106/L for average) with predominance of lymphocytes. Among 107 severe patients, EV71 was positive in 70, including all 10 critical cases. Conclusion Involvement of nervous,respiratory and digestive symptoms is common in severe cases of HFMD, and EV71 is the predominant pathogen.
