Preliminary study of alleviating new onset diabetic NOD mice by a DPP-Ⅳ inhibitor
10.3760/cma.j.issn.1000-6699.2010.12.016
- VernacularTitle:二肽基肽酶Ⅳ抑制剂治疗NOD小鼠新发糖尿病初步研究
- Author:
Lei TIAN
;
Yan ZHOU
;
Xingan QIN
;
Yongyao GU
;
Xianghua WU
;
Jiehua LI
;
Xiaolong GUI
- Publication Type:Journal Article
- Keywords:
Non-obese diabetic mice;
Dipeptidyl peptidase Ⅳ inhibitor;
NVP-DPP728
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(12):1069-1071
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effect of NVP-DPP728, a DPP-Ⅳ inhibitor on new-onset diabetes and the autoimmune response in non-obese diabetic ( NOD ) mice. Diabetes could be reversed in 75% of NVP-DPP728 treated 20 NOD mice. In these 15 mice with remission, insulitis scores were significantly lower than those of the control group. The percentage of Tregs was increased in the thymus and celiac lymph nodes, plasma TGF-β1 and GLP-1 were also significantly increased ( P＜0. 01 ). NVP-DPP728 treatment may reverse new-onset diabetes in NOD mice by reducing insulitis and increasing Tregs.
