Tumor necrosis factor -α, interleukin-6 and C reactive protein are involved in the function of islet β-cell in asthma
10.3760/cma.j.issn.1008-1372.2010.12.005
- VernacularTitle:TNF-α、IL-6和CRP对哮喘病人胰岛β细胞功能的影响
- Author:
Shaodan JIA
;
Weizhong ZHANG
;
Jing LI
;
Haiyan WANG
;
Zhixiu XIAO
;
Xiaoxia WANG
;
Weiyi ZHANG
;
Xia JI
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-alpha/BL;
Interleukin-6/BL;
C-reactive protein/BL;
Asthma/BL/PA;
Islets of langerhans/CY
- From:
Journal of Chinese Physician
2010;12(12):1599-1602
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between inflammatory cytokines and islet β-cell function in chronic persistent asthma patients. Methods 112 adults with persistent asthma and 60 healthy volunteers were enrolled in this study. According to the severity of disease, all subjects were divided into persistent-mild group and persistent-moderate group. Plasma tumor necrosis factor-α(TNF-α), interleukin6(IL-6) and C-reactive protein (CRP) were determined. Oral glucose tolerance and insulin releasing test were performed. The ratio of the area under the curve of insulin to area under the curve of glucose ( AUC1/AUCG ), homeostasis model assessment for insulin resistance ( HOMA-IR), insulin sensitivity index( ISI),homeostasis model assessment for β-cell function (HBCI) and early insulin secretion index(△I30/△G30)were calculated. The values of forced expiratory volume in l second ( FEV1 ), forced vital capacity(FVC)and FEV1/FVC were recorded. Results In patient groups, the values for plasma TNF-α, IL-6, CRP,AUC1, AUC1/AUCG, HOMA-IR, HBCI significantly increased compared with those in control group, while ISI declined ( t =2. 02～13.62, P ＜0. 05). Multiple step regression analysis showed that HOMA-IR was positively correlated with CRP, LDL-C, BMI, AUC1, TNF-α( P ＜0. 01 orP ＜0. 05), but negatively correlated with FEV1 ( P ＜ 0. 05 ). Conclusion The results indicated that inflammatory cytokines ( TNF-α,IL-6,CRP) might result in insulin resistance in asthma patients who had hyperinsulinism at the same time.
