Impaired cognition function after isoflurane inhalation versus propofol intravenous anesthesia in off-pump CABG patients
10.3760/cma.j.issn.1674-6554.2010.11.004
- VernacularTitle:异氟烷与丙泊酚对非体外循环冠脉搭桥患者术后认知功能的影响
- Author:
Chuzhang CHAO
;
Lei LI
;
Weifu LEI
;
Jianchun FEI
- Publication Type:Journal Article
- Keywords:
Coronary artery bypass grafting;
Off-pump;
Cognitive function;
Propofol;
Isoflurance
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(11):970-971
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the postoperative cognition function after propofol intravenous versus isoflurane inhalation anesthesia in off-pump coronary artery bypass grafting (CABG) patients. Methods 30 ASA Ⅱ - Ⅲ patients undergoing off-pump CABG were randomly assigned to two groups. Following induction of anesthesia,isoflurane inhalation( group A ) or propofol intravenous (group B ) were adjusted to maintain comparable depth of anesthesia state. The mini-mental state examination (MMSE) was used to assess the cognitive function 1 day before and 4 days after the operation. Results There were 5 patients suffered postoperative cognitive dysfunction in group A, and 3 cases in group B . But compared with the preoperative( group A (29.13 ± 0. 83 ), group B (29.13 ±1. 13 ) ) ,the MMSE score at 4 days in group A ( 28.73 ± 1.03 ) were lower( t = 2.45, P ＜ 0.05 ), there was no difference in group B( 28.93 ± 1.16)at 4 days( t = 1.87, P ＞ 0. 05 ). Conclusion Both propofol intravenous anesthesia and isoflurane inhalation anesthesia in off-pump CABG may contribute to postoperative cognitive dysfunction, propofol intravenous anesthesia is advantageous over isoflurane inhalation anesthesia.
