Analysis of neo-adjuvant chemotherapy in the treatment of 32 cases of cervical cancer
10.3760/cma.j.issn.1008-6315.2010.12.011
- VernacularTitle:宫颈癌新辅助化疗32例临床观察
- Author:
Min DU
;
Li TANG
- Publication Type:Journal Article
- Keywords:
Neo-adjuvant chemotherapy;
Cervical cancer;
Removal rate of surgery;
Quality of life
- From:
Clinical Medicine of China
2010;26(12):1257-1259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of neo-adjuvant chemotherapy in the treatment of cervical cancer. Methods A total of 32 patients,of which 12 cases of Ⅰ b2,8 cases of Ⅱ a,5 case of Ⅱ b and 7 cases of Ⅲ, were all treated with 2 - 3 cycles of PF chemotherapy before treatment with cisplatin 100 mg/m2, d 1;5-fluorouracil 1000 mg/m2 ,d1-5. The chemotherapy was performed for 3 weeks followed by three weeks rest as one cycle. Results Short-term effect was 81.3% (26/32), with 3 cases of Ⅰ b2 and 1 cases of Ⅱ a had been completely relieved after 2 - 3 cycles of chemotherapies. Simultaneously, chemotherapy improved the removal rate of surgery. Among these 32 patients, there were 4 cases achieved complete response (CR) ,22 cases achieved partial response (PR) ,5 case of stable disease ( SD), 1 cases of progressive disease(PD). The overall response rate( CR +PR) was 81.3% (26/32) ,and the control rate ( CR + PR + SD) was 96. 9% (31/32). The main adverse events included myelosuppression and gastrointestinal response, which were all tolerable. Conclusions The neo-adjuvant chemotherapy reduced the size of cancer,which can improve removal rate of surgery and the quality of life.
