Study on the efficacy and safety of ultrasound ablation in treatment of uterine fibroids
10.3760/cma.j.issn.0529-567x.2010.12.007
- VernacularTitle:超声消融治疗子宫肌瘤的安全性及有效性
- Author:
Wenzhi CHEN
;
Liangdan TANG
;
Wuwei YANG
;
Yan ZHANG
;
Jing LI
;
Wenxiu XIA
;
Jiemin ZHOU
;
Baorang ZHU
;
Chunquan ZHAO
;
Hua LINGHU
;
Jinyun CHEN
;
Li ZHU
;
Yongbin DENG
;
Zhibiao WANG
- Publication Type:Journal Article
- Keywords:
Uterine neoplasms;
Leiomyoma;
Ultrasonic therapy;
Catheter ablation;
Magnetic resonance imaging;
Reproducibility of results
- From:
Chinese Journal of Obstetrics and Gynecology
2010;45(12):909-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the safety and efficacy of ultrasound ablation in treatment of uterine fibroids. Methods Ninety-nine patients with 117 leiomyomas in total treated by Haifu JC focused ultrasound tumor therapeutic system were enrolled in prospective and non-randomized clinical trial in First Affiliated Hospital of Chongqing Medical University and Academy of Military Medical Sciences. Ultrasound ablation was performed guided by real-time ultrasonography under conscious sedation for single session. All patients were followed up at 6 months after treatment. On the day of treatment and after 1 month, patients were given by magnetic resonance imaging(MRI) exam to evaluate the effect of fibroids ablation. At 3 and 6months after treatment, the ratio of ablated area and volume reduction of fibroids more than 50% were evaluated by MRI exam again. The symptoms improvements were evaluated by uterine fibroid symptom (UFS) and complications were analyzed by guideline of society of international radiation (SIR). Results The average ablated area ratio of the target fibroid was (76 ± 24)%. The average reduction in fibroid volume determined by MRI at 3 and 6 months after treatment was (45 ± 21)% and (59 ± 26)%. Which were significantly decreased than those before treatment (P < 0. 05). At 6 months after treatment, 84. 6% (99/117) of patients showed more than 50% volume reduction, the rate of improved symptom score was 92%(66/72). All patients could resume normal daily activities at 2 hours after treatment. The adverse reactions of SIR C - D included delayed hospitalization, repeat treatment and increased level of nursing. E - F included permanent sequelae and death. In this study, no adverse reactions of C - F were recorded. Common complications (SIR A- B, only observation or simple management without sequelae) were 35% (35/99).Four cases with adverse reactions B of SIR were found, including 2 cases with skin burning of degree Ⅱ and 2 cases with febrile, they were administered by symptomatic therapy and changing dressing The other adverse reaction A of SIR included sorness of buttock, vaginal discharge, dysuria and painful urination, they were only suggested by follow-up. Conclusion It was efficacy and safe that ultrasound ablation as a single strategy were used in treatment of uterine fibroids.
