Diagnosis capability of macular ganglion cell complex and retinal nerve fiber layer thickness for glaucoma using Fourier optic coherence tomography
10.3760/cma.j.issn.1008-1372.2010.12.006
- VernacularTitle:傅立叶光学相干断层扫描测量黄斑区节细胞复合体及视网膜神经纤维层厚度对青光眼的诊断意义
- Author:
Haitao ZHANG
;
Hongjun ZHU
;
Baojun WANG
;
Yingying XU
- Publication Type:Journal Article
- Keywords:
Tomography,optical coherence/MT;
Macula lutea/CY/PP/RA;
Retina/PP/RA;
Nerve fibers/PA/PH/RA;
Glaucoma/PA/RA/DI
- From:
Journal of Chinese Physician
2010;12(12):1603-1607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore diagnosis capability of macular ganglion cell complex (mGCC)and peripapillary retinal nerve fiber layer(pRNFL) thickness for glancoma. Methods Adult outpatients received ocular regular examinations of glaucoma in our hospital were enrolled in this study. Parameters of pRNFL and mGCC measured by Fourier optic coherence tomography(OCT) were evaluated. Results 116 subjects ( 116 eyes) included 51 (44. 0% ) normal subjects, 30(30. 2% ) early glaucoma patients and 35 (25.9%) advanced glaucoma patients. There were significantly different pRNFL and mGCC thickness among the three groups ( F = 83.022,97. 361,27. 899,79. 585,140. 686,119. 166,116. 234, 90. 855,64. 341,133.064, P ＜0. 0l ). Area under Receive Operated Curve (AROC) of all pRNFL parameters in early glaucoma except nasal ( P ＞ 0. 05 ) and mGCC parameters had significantly diagnostic capability ( Need to be corrected by authors) ( pRNFL:0. 796 ±0. 049;mGCC:0. 748 ±0. 055, P ＜0. 05). As to the whole glaucoma, AROC of pRNFL and mGCC parameters had significantly diagnostic capability ( pRNFL:0. 889 ±0. 029; mGCC: 0. 862 ±0. 034, P ＜0. 01 ). Through AROC pairwise comparisons, the diagnosticpower of almost pRNFL and mGCC parameters had no difference ( P ＞ 0. 05) except that temporal, superior pRNFL thickness were significant higher than focal loss of volume (FLV) of mGCC ( P ＜ 0. 05 ). Conclusion The measurement of pRNFL thickness might still be used as a main method on diagnosis of glaucoma and mGCC could serve as a new beneficial complement tool for detection of glaucoma.
