Expression of COX-2 and VEGF in non-hodgkin lymphoma and its clinical significance

VernacularTitle:COX-2与VEGF在非霍奇金淋巴瘤中的表达及临床意义
Author: Yan SUN ; Xiaoxia CHU ; Guohua YU ; Lei JIANG
Publication Type:Journal Article
Keywords: Prostaglandin-endoperoxide synthases/ME; Vascular endothelial growth factors/ME; Lymphoma,non-hodgkin/ME
From: Journal of Chinese Physician 2010;12(12):1623-1627
CountryChina
Language:Chinese
Abstract: Objectiye To explore the expression of COX-2 and VEGF and its clinical significance in non-Hodgkin lymphoma (NHL). Methods The expression of COX-2 and VEGF were detected by immunohistochemistry in 42 cases of NHL and 20 cases of lymph node with benign pathological change. Results The positive rate of COX-2 and VEGF was 45.24% and 73.81% in NHL respectively. The expression rate of VEGF was positively correlated with that of COX-2 in tissues of NHL ( x2 = 4. 63, P ＜ 0. 05).The expression of COX-2 was related to clinical stage and histopathologic grade of NHL ( x2 = 5.43, P ＜0. 05), but it had no association with gender, age, B symptoms, and IPI. The expression of VEGF was significantly related with aggression, B symptoms and IPI ( x2 =8. 979, 8. 893,6. 434, P ＜0. 05), but it had no association with age, gender and clinical stages. Conclusion COX-2 and VEGF may be involved in NHL tumorgenesis, and COX-2 may accelerate angiogenesis by increasing VEGF expression. Specific COX-2 inhibitors may be a novel therapeutic approach for NHL.