Value of serum cystatin C for early diagnosis of renal damage in patients with liver cirrhosis

VernacularTitle:血清胱抑素C对肝硬化病人肾功能损害的早期诊断价值研究
Author: Bo LI ; Song SU ; Zhongneng YANG ; Yong WANG ; Dong MU ; Qingwei ZOU ; Kai HE ; Xianming XIA
Publication Type:Journal Article
Keywords: Liver cirrhosis; Renal damage; Cystatin C
From: Chinese Journal of Hepatobiliary Surgery 2010;16(12):922-924
CountryChina
Language:Chinese
Abstract: Objective To investigate the diagnostic value of serum Cystatin C for early detection of renal damage in patients with liver cirrhosis. Methods 24-h creatinine clearance (CCr), serum level of cystatin C (CysC) and serum creatinine were measured in 76 patients with cirrhosis and t-test,Pearson's correlation test and ROC curve were used to evaluate the diagnostic significance of Cys C.Results The increase in Cys C level was associated with a decrease of CCr in the patients. Both Cys C and SCr were inversely correlated with CCr ( CysC: r =- 0. 763, P ＜ 0. 001; SCr: r=-0. 571,P＜0.01). Meanwhile, the area under the ROC curve was significantly higher in Cys C than in SCr (0. 830 vs. 0. 612). Conclusion Cystatin C is a more accurate and sensitive marker of renal diagnosis in liver cirrhosis. Detection of Cys C level in cirrhotic patients is of great significance for the prevention of liver-kidney syndrome.