Diagnostic value of combined determination of serum CA125,TSGF and DD levels in patients with ovarian cancer
10.3760/cma.j.issn.1008-6706.2010.23.003
- VernacularTitle:血清糖蛋白、恶性肿瘤特异性生长因子及D-二聚体联合检测对卵巢癌的诊断价值
- Author:
Xia CHENG
- Publication Type:Journal Article
- Keywords:
Ovarian Neoplasms;
Carbohydrate antigen 125;
Tumor specific growth factor;
D-dimer
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(23):3173-3174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value ofcombined detection of the serum levels of CA125,TSGF and DD in the diagnosis of ovarian cancer. MethodsThe serum CA125 and DD were determined by enzyme linked immunosorbent assay and TSGF was determined by biochemistry shade selection in all 252 patients(including 84 cases of ovarian cancer,84 cases of ovarian benign diseases,84 cases of controls). ResultsThe concentration of CA125,TSGF and DD in the diagnosis of ovarian cancer group were higher than those in ovarian benign diseases group and the controls(all P＜0.05).There was no statistical significance in the concentration of CA 125,TSGF and DD between ovarian benign diseases group and the controls(all P ＞ 0.05).In combined assay of CA 125,TSGF and DD,the sensitivity rate was 94.05%,the specificity rate was 90.48%,and the accuracy rate was 92.26%.Comparing with the single assay,combined analysis had much higher diagnostic sensitivity(all P＜0.05). ConclusionThe assay of CA125,TSGF and DD had significant dinical value in diagnosis of breast cancer,combined detection could increase the positive detection of ovarian cancer,and compensate the use of only one tumor marker.
