Anticoagulation effect of low molecular weight heparin on hemodiafiltration by different forms of administration
10.3760/cma.j.issn.1008-6315.2010.12.024
- VernacularTitle:低分子肝素在血液透析滤过中不同给药方式的分析
- Author:
Jun LIANG
;
Baoying FAN
- Publication Type:Journal Article
- Keywords:
Hemodiafiltration;
Low molecular weight heparin
- From:
Clinical Medicine of China
2010;26(12):1296-1298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anticoagulation effect of low molecular weight heparin ( LMWH) on hemodiafiltration by different forms of administration. Methods Twenty-four uremic patients undertook hemodiafiltration were divided into ia and iv group randomly, acecepted single injection of LMWH. LMWH was administered to 12 patients by arterial injection ( predialyzer), while in the other 12 patients by venous injection (postdialyser). The APTT were measured before treatment and at 1 h,2 h,3 h time points after treatment in all patients. The dialysis fluid and blood levels of LMWH were measured at 2 minutes,5 minutes,1 h,2 h,3 h time points after the treatment started. Results The LMWH levels during hemodiafiltration were significantly higher in iv group than ia group (0.457 ± 0.073 ) U/ml vs. (0. 217 ± 0. 053 ) U/ml, t = 9. 702, P = 0. 001 ). However there were no significant APTT, dialyzer residual substance differences between two groups (P ＞ 0. 05 respectively )Conclusions Different ways of drug administration resulted in significantly different blood levels of LMWH, but did not affect the anticoagulant effect during hemodiafiltration, which would be related to LMWH absorption on dialysis membrant.
