Preliminary exploration of the frontal-cingulate functional connection during identifying sad facial expression in depressed patients
10.3760/cma.j.issn.1674-6554.2010.12.001
- VernacularTitle:抑郁症患者识别悲伤表情时额叶-扣带回功能连接的初步研究
- Author:
Gang LIU
;
Qing LU
;
Jing ZHANG
;
Haiyan LIU
;
Zhijian YAO
- Publication Type:Journal Article
- Keywords:
Depression;
Functional connection;
Dynamic causal modeling(DCM)
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(12):1057-1059
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the difference of frontal-cingulate functional connection between patients with major depression and healthy controls in recognization of sad facial expression, and discuss the neutral basis of emotional bias in preliminary. Methods 12 female patients with major depression and 12 matched healthy controls were scanned. The intensities of brain activation in the process of sad and neutral facial expression recognition were analyzed, and the strengths of frontal-cingulate functional connection were compared between the two groups based on dynamic causal modeling. Results Comparing the stimulus adjusting connection models with Bayesian model indicated that model Ⅱ matched with the observation data better. In the comparison between model Ⅱ and model I ,the average Bayes factor was more than 7.38. In the comparison between model Ⅱ and model Ⅲ,the average Bayes factor was more than 2.71. Calculating the intrinsic connection parameters and stimulus adjusting connection parameters based on intrinsic connection model and stimulus adjusting connection model( model Ⅱ ), the result showed that connection strength between anterior cingulate and right inferior frontal gyrus in depression was greater than that in healthy controls. Conclusion The frontal-cingulate functional connection of patients with major depression is increased abnormally ,which may be the neural basis of negative emotional bias.
