Effects of Xuebijing on intestinal function and inflammatory responses in patients with severe burn
10.3760/cma.j.issn.1671-0282.2010.12.022
- VernacularTitle:血必净对严重烧伤患者肠道功能及炎症反应的影响
- Author:
Chen CAI
;
Qinglian XU
;
Hong HU
;
Yizhong TANG
;
Weiwei QI
- Publication Type:Journal Article
- Keywords:
Xuebijing;
Burns;
Diamine oxidase;
Lipopolysaccharide;
Tumor necrosis factor-α;
Interleukin-6
- From:
Chinese Journal of Emergency Medicine
2010;19(12):1317-1319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Xuebijing injectio (Chinese herb preparation) on intestinal function and inflammatory responses in severe burn patients. Method Thirty-two patients with comparable severity in burn injury were randomly divided into Xuebijing injectio treatment group (n = 16) and control group (n = 16). Patients in both groups received routine burn therapy, while those in Xuebijing treatment group additionally received Xuebijing injectio 100mL in intravenous drip twice a day for 7 days. Before the treatment and on the 3rd and the 7th day after the treatment, blood concentrations of diamine oxidase (DAO), lipopolysaccharide (LPS) ,tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) were determined in both groups. Analysis was made by SPSS 12.0 software. Results The plasma levels of DAO, LPS, TNF-α and IL-6 were decreased in both groups after the treatment. However, the plasma levels of DAO, LPS, TNF-α and IL-6 in the Xuebijing treatment group were significantly lower than those in control group on the 3rd and 7th day after the treatment (P＜ 0.05).Conclusions Xuebijing injectio could protect intestinal function, decrease the plasma level of endotoxin and lessen zhe inflammatory responses in severe burn patients.
