Experimental study of the stachyose, an extract of Chinese herbal medicine, in rats functional bowel disorder induced by stomach irritation with cool water
10.3760/cma.j.issn.1008-1372.2010.12.004
- VernacularTitle:中药提取物水苏糖对冰水灌胃应激后肠功能紊乱大鼠作用的实验研究
- Author:
Zhifu LI
;
Ke ZHAO
;
Weidong WANG
;
Jun ZHU
- Publication Type:Journal Article
- Keywords:
Lactulose/PD;
Plant extracts/PD;
Irritable bowel syndrome/DT/ET;
Ice/AE;
Constipation/DT;
Intestines/MI
- From:
Journal of Chinese Physician
2010;12(12):1594-1598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regulatory effects of stachyose through oral administration on the facilitating feces excretion function and its relationship to the intestinal flora in stomach irritation with cool water-induced functional bowel disorder rats. Methodes Stomach irritation with cool water -induced constipation-predominant irritable bowel syndrome model rats were administrated by i.g. with stachyose at intestine were determined within 12 hours on the 7th and 14th day after stachyose administration, and intestine flora was measured on the 14th day after Stachyose administration. Results The feces granules and the moisture contests of feces and the efficiency of the small intestine were increased in stachyose treated C-IBS rats, and the number of intestinal flora was significantly higher than that in the control C-IBS rats [ (38.43±4.57) grain VS (32. 21 ± 3.43) grain, F = 3.892, P ＜ 0.05; (47. 88 ± 3.43)% VS (43. 18 ±6.85)%, F =6.724, P ＜0.01;(1.04±0. 11)radian VS (0. 88 ±0.08)radian, F =4.965, P ＜0.05;(10.77 ±0.44)1g(CFU/g) VS (9.85 ±0.43)1g(CFU/g), F =7.613, P ＜0.01;(10.96±0.35)lg(CFU/g) VS (9. 84 ±0. 35)1g(CFU/g), F = 10. 413, P ＜0. 01 ]. Conclusion The results indicated that the stachyose,an extract of Chinese herbal medicine, had the facilitating feces excretion function and modulation functionon intestinal flora in stomach irritation with cool water-induced functional bowel disorder rats.
