Ultrasound evaluation of neoadjuvant chemotherapeutic response in breast cancer and its correlation with histopathology
10.3760/cma.j.issn.1004-4477.2010.12.017
- VernacularTitle:乳腺癌新辅助化疗疗效的超声评价及与组织病理学的相关性
- Author:
Yaling CHEN
;
Wei ZENG
;
Cai CHANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Breast neoplasms;
Antineoplastic combined chemotherapy protocols
- From:
Chinese Journal of Ultrasonography
2010;19(12):1059-1063
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study ultrasound features of breast cancer before and after neoadjuvant chemotherapy,and its correlation with histopathology. Methods One hundred and nine patients with breast cancer underwent paclitaxel plus carboplatin neoadjuvant chemotherapy, the change of the primary lesions and axillary lymph nodes were studied by ultrasound,and compared with histopathology. Results Seventeen patients achieved complete remission under ultrasound, the rest measurable lesions became significantly shortened in maximum diameter [ ( 22.46 ± 11.50) mm vs (34. 71 ± 13.67) mm, P ＜ 0. 001 ], and showed decrease both in longitudinal-transverse ratio (0. 80 ± 0. 23 vs 0. 86 ± 0. 22, P ＞0. 05) and grades of blood flow (0. 51 ± 0.80 vs 1.23± 1.05, P ＜0. 001 ). 44. 83% (44/92) of metastatic axillary lymph nodes disapeared after treatment. Comparing with histopathology, the sensitivity and specificity of ultrasound assessing complete remission were 57. 89 % ( 11 / 19) and 93.33 % (84/90), respectively. The moderate concord between ultrasound with histopathology might be attributed to the pathologic change of breast tissue and stroma after treatment, nevertheless grades of blood flow might be more meaningful. Conclusions Ultrasound assessment of neoadjuvant chemotherapeutic response might be of reference value,and studying corresponding ultrasonic manifestation of different kinds of pathological changes would help with better evaluation.
