Relation of HCC to loss of heterozygosity
10.3760/cma.j.issn.1007-8118.2010.12.027
- VernacularTitle:肝细胞癌与杂合性缺失的关系
- Author:
Wuhua ZHOU
;
Lin ZHOU
;
Shusen ZHENG
- Publication Type:Journal Article
- Keywords:
Microsatellite;
Tumor suppressor gene;
Neoplasm recurrence
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(12):969-972
- CountryChina
- Language:Chinese
-
Abstract:
The carcinogenesis of primary liver cancer is a complicated multi-factor, multi-step, multi-gene process.Hepatocellular carcinoma (HCC) is the most important type of primary liver cancer. Allele deletions and inactivation of tumor suppressor genes (TSGs) play critical roles during the carcinogenesis, progress and recurrence of HCC. Loss of heterozygosity (LOH) associated with HCC occurs at most autosomes and the Y chromosome. Losses at chromosomes 1p, 1q, 4q, 8p, 10q, 16q, and 17p have been documented frequently. In this article, we previewed the investigations of clinical significance of LOH, and looked forward to the application of LOH in early detection, therapy, and prediction of prognosis and susceptibility in HCC patients.
