Advances in research of miR-15's role in malignant tumors
10.3760/cma.j.issn.1673-422X.2010.09.004
- VernacularTitle:微小RNA miR-155在肿瘤中的研究
- Author:
Haidong LI
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Neoplasms;
Gene expression regulation
- From:
Journal of International Oncology
2010;37(9):652-654
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA-155 (miR-155) is over-expressed in many human malignant tumors. Recent studies have shown that miR-155 plays a crucial role in tumor development and is closely related to disease prognosis. It is found that miR-155 promotes tumor growth,invasion and metastasis through inhibition of downstream targets such as SHIP1、C/EBPβ、SCOS1 、TP53INP1. The expression level of miR-155 can be used as a marker for the early diagnosis of malignant tumors, and inhibition of miR-155 expression may become a novel approach for cancer treatment.
