Fluorescence in situ hybridization in multiple myeloma
10.3760/cma.j.issn.1673-422X.2010.09.020
- VernacularTitle:荧光原位杂交在多发性骨髓瘤中的应用
- Author:
Feifei HUO
- Publication Type:Journal Article
- Keywords:
In situ hybridization,Fluorescence;
Multiple myeloma;
Chromosome aberrations
- From:
Journal of International Oncology
2010;37(9):703-706
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma (MM) is a malignancy of the plasma cells, characterized by complex karyotype and chromosome instability. These cytogenetic changes are important prognostic indicators in MM patients. Fluorescence in situ hybridization (FISH) can analyze a large number of interphase cells without metaphase. It is simple, reproducible, highly sensitive and specific. It has more prominent advantages in the research of MM without informative metaphase. FISH can detect microdeletions in genetic loci that are closely related to disease prognosis, therefore significantly improves the abnormal clone detection rate. FISH provides a theoretical foundation for the diagnosis, clinical classification and prognosis prediction, and can guide the personalized therapy of MM.
