The influence of continuous high volume hemofiltration on respiratory mechanics and hemodynamics in patients with multiple organ dysfunction syndrome
10.3760/cma.j.issn.1673-4904.2011.01.005
- VernacularTitle:高容量血液滤过对多器官功能障碍综合征患者呼吸力学和血流动力学的影响
- Author:
Jian XIE
;
Jun YANG
;
Tao LI
;
Yongqing XU
;
Zhiming JIANG
;
Ming ZHANG
;
Zhonghui ZHANG
- Publication Type:Journal Article
- Keywords:
Hemofiltration;
Multiple organ failure;
Respiratory mechanics;
Hemodynamics
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of continuous high volume hemofiltration (HVHF)on respiratory mechanics and hemodynamics in multiple organ dysfunction syndrome (MODS). MethodsForty-one adult patients with MODS who received mechanical ventilation were divided into HVHF group(21 cases) and continuous vein-vein hemofiltration (CVVH) group (20 cases) by envelople. The peak airway pressure (Ppeak), dynamic pulmonary compliance(Cdyn), cardiac output(CO ), systemic vascular resistance(SVR), pulmonary vascular resistance (PVR) and blood gas analysis before treatment and 24 hours after treatment were measured. Results Twenty-four hours after treatment, the levels of Ppeak, Cdyn, CO, PVR,SVR and oxygenation index were (31.32 ±2.23) cm H2O (1 cm H2O =0.098 kPa), (26.18 ±3.54)(220.41 ±21.41) mm Hg (1 mm Hg =0.133 kPa) respectively in HVHF group,significantly higher than those before treatment [(42.00 ±3.34) cm H2O, (17.91 ±4.31) ml/cm H2O, (8.68 ±1.17) L/min,(267.27 ± 16.29) dyn·s·cm-5, (805.32 ± 18.82)dyn ·s·cm-5, ( 119.41 ± 17.10) mm Hg] (P ＜ 0.01 ),as well as higher than those in CVVH group after 24 hours' treatment (P ＜ 0.01 ). ConclusionHVHF shows significant beneficial effects on respiratory mechanics and hemodynamics of MODS.
