Long-term results of nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone
10.3760/cma.j.issn.1004-4221.2011.01.001
- VernacularTitle:早期鼻咽癌单纯调强放疗的远期疗效评价
- Author:
Shengfa SU
;
Chong ZHAO
;
Fei HAN
;
Chunyan CHEN
;
Weiwei XIAO
;
Jiaxin LI
;
Taixiang LU
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms/radiotherapy;
Radiotherapy,intensity-modulated;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2011;20(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the outcomes and toxicities of early stage nasopharyngeal carcinoma(NPC)patients treated with intensity-modulated radiotherapy(IMRT)alone. Methods From February 2001 to January 2008, 198 early stage NPC patients according to AJCC/UICC 2002 staging system were treated by radical radiotherapy with IMRT technique in our institute, the clinical data were analyzed retrospectively. Results The 5-year disease-specific survival, local recurrence-free survival(LRFS)and distant metastasis-free survival(DMFS)were 97.3%, 97.7% and 97. 8% respectively. The 5-year LRFS for T1, T2 patients were 100%, 96. 7%(x2 = 2. 24 ,P = 0. 135)respectively. The 5-year DMFS for T1 N0,T2N0, T1N1, and T2N1 patients were 100%, 98. 8%, 100% and 93. 8%(x2= 2. 35, P= 0. 125)respectively. Grade 1 and 2 mucositis and pharyngitis were most common acute toxicities. Radiation encephalopathy and cranial nerve injury were not observed in all patients. Conclusions IMRT alone for early stage NPC patients can produce satisfactory results and acceptable treatment-relative toxicities. Patients with T2b and T2bN1 had a relatively higher incidence of local recurrence and distant metastasis, which suggested that combination of IMRT and chemotherapy may improve clinical results in those patients.
