Delayed hypersensitivity to infliximab retreatment in two patients and literature review
10.3760/cma.j.issn.0578-1426.2011.01.015
- VernacularTitle:再次输注英夫利西单抗引起迟发过敏反应二例并文献复习
- Author:
Kunpeng LI
;
Jianglin ZHANG
;
Jian ZHU
;
Wei ZHAO
;
Feng HUANG
- Publication Type:Journal Article
- Keywords:
Infliximab;
Anaphylaxis;
Spondylitis,ankylosing
- From:
Chinese Journal of Internal Medicine
2011;50(1):52-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the understanding of severe anaphylactic reactions to infliximab retreatment. Methods Delayed hypersensitivity to infliximab in two patients with ankylosing spondylitis who had previously received infliximab and resumed after discontinuation over 4 years were reported and the related literatures were reviewed. Results Two patients ( 1 male, 1 female ) who were diagnosised with ankylosing spondylitis for more than 10 years, both individuals had received infliximab treatment during a clinical trial approximately 4-5 years prior to further therapy. On day 6 after subsequent infusion, one patient had pruritic skin rash covering her whole body, followed by flustered, dyspnea, hypotension and anaphylactic shock, she was successfully treated with epinephrine and glucocorticoid. Another patient experienced a skin rash and itching 9 days after reinfusion, he was successfully treated with antihistaminics.Conclusion A distant infliximab retreatment is associated with high rates of reinfusion reactions, including fever, urticaria, myalgia, arthralgia,even hypotension, dyspnea, laryngeal edema and anaphylactic shock.We recommend careful monitoring of those patients who receive infliximab retreatment, particularly after a lengthy interval.
