The therapeutic effects of highly active anti-retroviral therapy in 74 treatment-naive patients with AIDS in China
10.3760/cma.j.issn.0578-1426.2011.01.017
- VernacularTitle:高效抗逆转录病毒治疗对74例艾滋病初治患者三年疗效观察
- Author:
Xiejie CHEN
;
Xiaoping TANG
;
Weiping CAI
;
Jiansheng ZHANG
;
Jinfeng CHEN
;
Qicai LIU
;
Huolin ZHONG
;
Haolan HE
;
Linghua LI
;
Bin ZHAO
;
Hong SHANG
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
CD4 lymphocyte count;
Viral load;
Highly active anti-retroviral therapy
- From:
Chinese Journal of Internal Medicine
2011;50(1):59-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect of highly active anti-retroviral therapy (HAART) in treatment-na(i)ve Chinese patients with AIDS, to provide evidences for standardizing HAART.Methods Seventy-four treatment-naive AIDS patients were initiated with HAART and followed up regularly for 3 years. The clinical and laboratory data, side effects and drug resistance were observed and analyzed during the follow-up period. Results Of the 74 patients, 46 were males and 28 were females, with the average age being 42 years. The mean HIV viral load was ( 2. 2 ± 2.0 ) × 105 copies/ml and the baseline mean CD4+ T lymphocyte count was (62 ± 71 )cells/μl before treatment. After treatment for 3, 6, 12, 18,24, 30 and 36 months, the percentage of undetectable HIV viral road (less than 50 copies/ml ) was 71.6%, 83.8%, 75.7%, 77.0%, 82.4%, 81.1% and 79.7% respectively, and CD4+T lymphocyte count ascended to ( 167 ± 105), ( 177 ± 129), (238 ± 137), (290 ± 158), (304 ± 191 ), (331 ± 175) and ( 352 ± 202 ) cells/μl. The increase in amplitude of CD4+ T lymphocyte count in different periods examined was different, with the period of 0-3 months post-treatment demonstrating the most obvious augmentation ( P ＜ 0. 01 ) . The most common adverse reactions were liver function injury ( 52/74,70. 3% ), hyperlipemia (52/74, 70. 3%), hematopoietic inhibition of the bone marrow (33/74, 44. 6% ),peripheral neuritis (32/74, 43.2% ) and lipoatrophy (26/74, 35. 1%). Clinical drug resistance were found in nine patients and HIV gene mutations were detected in these patients. Conclusions Chinese treatment-naive AIDS patients have achieved good virological and immunological response to generic-drugpredominant HAART regimes with low drug resistance, but relatively more side effects.
