Lipoprotein-associated phospholipase A2:an independent predictor of vascular risk and a novel target for therapy
10.3760/cma.j.issn.1673-4165.2010.09.013
- VernacularTitle:脂蛋白相关磷脂酶A2:一种独立血管风险预测因子和治疗新靶点
- Author:
Guoqing ZHOU
;
Yongjun CAO
;
Heqing ZHAO
- Publication Type:Journal Article
- Keywords:
1-Alkyl-2-acetylglycerophosphocholine esterase;
Phospholipases A2;
Atherosclerosis;
Coronary artery disease;
Stroke;
Brain ischemia;
Macrophages;
Apoptosis
- From:
International Journal of Cerebrovascular Diseases
2010;18(9):702-705
- CountryChina
- Language:Chinese
-
Abstract:
Lipoprotein-associated phospholipase A2(Lp-PLA2) can rapidly hydrolize and oxidize the oxidized phosphatidylcholine molecules produced in low density lipoprotein and atherogenic lipoprotein (a),generating the soluble proinflammatory and proapoptotic mediatorslyso-phosphatidylcholine and oxidized free fatty acids.It stimulates aggregation and activation of monocyte-macrophage system and induces apoptosis and damages the removal of dead cells.It plays an important role in the development of lipid necrotic core of atherosclerosis.Lp-PLA2 is not an independent risk marker of coronary artery disease and ischemic stroke,but also plays an important role in the development of atherosclerotic plaques.Selective Lp-PLA2 inhibitor reduces the development of necrotic cores.It may play a role in the stabilization of atherosclerotic plaques.At the same time,it may represent a novel target for the treatment of atherosclerosis.
