Observation of the effect of valsartan combined with benazepril in treatment of patients with chronic heart failure

VernacularTitle:缬沙坦联合贝那普利治疗慢性心力衰竭的疗效观察
Author: Yancai JIA
Publication Type:Journal Article
Keywords: Valsartan; Benazepril; Chronic heart failure
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(20):2780-2782
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of valsartan combined with benazepril in treatment of patients with chronic heart failure. Methods 60 patients with heart failure of New York Heart Association (NYHA) class Ⅱ -Ⅳ and LVEF less than or equal 40% were selected and randomly divided into two groups. The patients in control group were given benazepril(10mg/d) alone,and the patients in treatment group were given valsartan(80mg/d) combined with benazepril(10mg/d). After 8 months therapy, the changes of the parameters of left ventriclular function and ventriclular dimension of the patients with chronic heart failure were compared before and after treatment. And the clinical efficacy was compared between two groups. Results The ventriclular dimension of the patients with chronic heart failure was decreased,and left ventriclular function was improved. The patients of the combination therapy group were improved especially after treatment. Conclusion Angiotensin-converting-enzyme(ACE) inhibitor could improve heart function of patients with chronic heart failure. Therapy of valsartan combined with benazepril was more effective.