Role and mechanism of telomerase reverse transcriptase in ischemic brain damage
10.3760/cma.j.issn.1673-4165.2010.09.014
- VernacularTitle:端粒酶逆转录酶在缺血性脑损伤中的作用和机制
- Author:
Jiao LI
;
Yi QU
;
Dezhi MU
- Publication Type:Journal Article
- Keywords:
Telomerase;
Catalytic domain;
DNA-binding proteins;
Brain iscbemia;
DNA damage;
Apoptosis
- From:
International Journal of Cerebrovascular Diseases
2010;18(9):706-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective Telomerase reverse transcriptase (TERT) participates in pathologic processes of many ischemic damages.It also plays an important role in ischemic brain damage.There are a lot of activation mechanisms of TERT after cerebral ischemia.At present,the hypoxia-inducible factor-1 has been more clearly studied.The protective effect of TERT in ischemic brain damage may be associated with anti-apoptosis,promoting cell survival,promoting angiogenesis,and protecting mitochondria.
