The relationship between expression of PIAS3 and malignancy of human brain meningioma

VernacularTitle:脑膜瘤恶性程度与活化的信号转导转录活化因子3蛋白质抑制剂表达的关系
Author: Tianhong PAN ; Lei SHI ; Shuguang ZHANG
Publication Type:Journal Article
Keywords: Meningeal; Protein inhibitors of activated STAT
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(21):2881-2883
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between PIAS3 expression and the degree of malignancy of meningiomas.Methods 72 cases of different degree of malignant meningioma and 13 cases of surgical specimens of normal brain tissue were extracted the total RNA,and detected the levels of PIAS3 in different degree of meningioma and normal brain tissue through comparative control study by using real-time fluorescence quantitative PCR.Results PIAS3 was low expressed in normal brain tissue,however,high expressed in the human brain meningioma with significant differences(P＜0.01).There were also significant differences found in expression level of PIAS3 between meningiomas grade I and Ⅱ,or Ⅲ level(P＜0.05),but the differences between meningiomas grade Ⅱ and Ⅲ were not obvious(P＞0.05).And PIAS3 expression was not related with the depth of infiltration in invasive meningiomas(P＞0.05).Conclusion PIAS3 was overexpression in meningiomas,and was be closely related to the occurrence and development of meningiomas.