Influence of different anesthesia methods on postoperative changes in T-lymphocyte subsets and cytokines in the patients under want operation of stomach carcinoma
10.3760/cma.j.issn.1008-6706.2010.21.005
- VernacularTitle:两种麻醉方法对胃癌手术患者血清T淋巴细胞亚群及炎性因子水平的影响
- Author:
Xifa SONG
;
Li CHEN
;
Zhaoxia LI
;
Chunsheng YU
;
Jiangdong LIU
- Publication Type:Journal Article
- Keywords:
Anesthesia;
Stomach neoplasms;
T-lymphocyte subsets;
Interleukins;
Tumor necrosis factor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(21):2889-2891
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of different anesthesia methods on postoperative changes in T-lymphocyte subsets and IL-6、IL-10、TNF-α in the patients undergoing operation of stomach carcinoma.Methods 60 patients with stomach carcinoma were randomly divided into group I(general anaesthesia)and Ⅱ(general combined epidural anesthesia).The level of T-lymphocyte subsets and IL-6、IL-10、TNF-αt were respectively detected and compared before anesthesia,2 h after anesthesia,ld and 6 d after operation.Results CD3+ 、CD4+ 、CD4+/CD3+ decreased,but IL-6 increased at the end of 2 h after anesthesia,l d after operation compared with those before anesthesia(all P＜0.05).While IL-10、TNF-α had no statistical significance(all P＞0.05).At 6 d after operation,the values recovered to the level before anesthesia in two groups.Conclusion The immune function in patients with gastric cancer decreaseed after anesthesia,it was more serious in geteral anaesthesia than that of general combined epidural anesthesia.But anesthesia had little influence on inflammatory response.
