Clinicopathological significance of expression of HIF-1α and P-gp in pancreatic carcinoma
10.3760/cma.j.issn.1007-8118.2011.01.011
- VernacularTitle:HIF-1α、P-gp在胰腺癌中的表达及其临床病理学的意义
- Author:
Jun LIU
;
Chen HUANG
;
Jing SUN
;
Honghui HU
;
Yubiao JIN
;
Zhengjun QIU
- Publication Type:Journal Article
- Keywords:
Pancreatic carcinomas Immunohistochemistry;
HIF-1α;
P-gp;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(1):36-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HIF-1α and P-gp protein in pancreatic carcinoma and determine their clinicopathological significance and the correlation between the expression of HIF-1α, P-gp and the clinical prognosis. Method In samples from 74 cases of pancreatic carcinoma and 10 healthy individuals, the expression of HIF-1α and P-gp were detected by immunohistochemical method. Results The positive expression rate of HIF-1α and P-gp was 75.7% and 86.5%,respectively, which were remarkably higher than that in normal pancreatic tissue (P＜0.05). There was a positive correlation between the expression of HIF-1α and that of P-gp. The aberrant expression of HIF-1α and P-gp was associated with lymph node metastasis but not the location, size, clinical stages and nerve invasion of the tumor. Patients with high intensity of HIF-1α and P-gp expression showed a significantly lower median survival time than those with low intensity expression.Conclusions The expression of HIF-1α and P-gp is up-regulated in pancreatic carcinoma and there is a positive correlation between them. The expression of HIF-1α and P-gp might be related to the lymph node metastasis and poor prognosis.
