Clinical significance of changes of T lymphocyte subtype and serum levels of leukotriene B4 in children with acute leukemia
10.3760/cma.j.issn.1008-6315.2011.01.034
- VernacularTitle:急性白血病患儿T淋巴细胞亚群及血清白三烯B4含量变化的临床意义
- Author:
Huiqin XUE
;
Ming LI
;
Lei ZHU
;
Rui ZHAO
;
Shixu ZHANG
;
Xueping WANG
- Publication Type:Journal Article
- Keywords:
Acute leukemia;
T lymphocyte subtype;
Leukotrienes B4
- From:
Clinical Medicine of China
2011;27(1):103-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of T lymphocyte subtype levels and serum levels of leukotriene B4 ( LTB4 )in children with acute leukemia (AL). Methods The activity of T lymphocyte subsets:CD3+ T cells,CD4+ T cells,CD8 + T cell levels and NK cell were detected in 40 cases of AL and 40 control by Flow Cytometry(FCM). The serum level of LTB4 was measured by ELISA in all subjects. ResultsCompared with normal control , the percentages of CD3 + T cells ( [ 49.51 ± 6.53 ] ％ vs [ 67.63 ± 5.23 ] ％ ), CD4 + T cells ([22.15±4.87]％ vs [34.43 ±5.07]％),CD8+ T cell ([23.41 ±3.96]％ vs [28. 17 ±4.61]％),NK cell ( [5.41 ± 4.25 ] ％ vs [ 13.10 ± 4.91 ] ％ ) were significantly lower in children AL patients, ( Ps ＜0.01 ). However,the serum levels of LTB4 increased significantly in AL patients compared with normal control ( [ 25.23 ± 6.24 ] ng/L vs [ 8.28 ± 2.53 ] ng/L, P ＜ 0.01 ). ConclusionT lymphocyte subtype and serum level of LTB4 showed significant changes in children AL patients compared with normal control, which revealed an important theoretical basis to AL pathogenesis.
