Relationship between interleukin-1β -31C/T polymorphism and susceptibility to gout in Chinese male population
10.3760/cma.j.issn.1007-7480.2011.01.003
- VernacularTitle:中国沿海地区汉族男性人群白细胞介素-1β-31C/T基因多态性与痛风的易感性研究
- Author:
Nan CHU
;
Changgui LI
;
Zhaotong JIA
;
Shiguo LIU
;
Lin HAN
- Publication Type:Journal Article
- Keywords:
Interleukin-1;
Polymorphism,single nucleotide;
Gout
- From:
Chinese Journal of Rheumatology
2011;15(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore gene polymorphism of the C/T genotype of rs1143627 in the promoter of IL-1β gene in male population living in the coastal area of Shandong, and thus to investigate the relationship between the gene polymorphism of IL-1β and gout. Methods A total of 208 gout patients and 210 healthy controls were enrolled. The possible association between the polymorphism of IL-1 β -3 1C/T and gout in Chinese were investigated and genotype frequencies and allelic frequencies was calculated by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. Hardy-Weinberg was used to verify the representativeness of the sample. Comparisons between the groups were performed with χ2 test and t-test. Results The frequencies of CC, CT, and TT genotypes were 32.7%, 43.3% and 24.0%,respectively among gout patients, while they were 31.9%,46.2% and 21.9%, respectively among the controls.There was no statistically difference in IL-1β -31C/T genotype frequencies between gout patients and controls (χ2=0.427, P>0.05). The allele frequencies of C and T in gout cases were different from those in the controls (54.3%, 55.0%; 45.7%, 45.0%; χ2=0.038, P>0.05). Moreover, no association between IL- I β-31 C/T genotypes and risk factors for gout were observed in gout cases by χ2 test. Conclusion Results of the present study suggest that the C/T genotype of rs1143627 in the promoter of IL-1β gene is not associated with gout in male population living in the coastal area of Shandong.
