Relationship between skin prick test reactivity to dermatophagoides farinae and autologous serum reactivity in patients with chronic urticaria

VernacularTitle:慢性荨麻疹患者粉尘螨变应原皮肤点刺反应与自体血清皮肤反应的关系
Author: Xiuying HUANG ; Xiaofang ZHOU ; Lin FENG ; Hua ZHONG ; Zhiqiang SONG ; Fei HAO
Publication Type:Journal Article
Keywords: Urticaria; Skin tests; Hypersensitivity
From: Chinese Journal of Dermatology 2011;44(1):15-17
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of and relationship between reactivity to autologous serum and dermatophagoides farinae (Df) in the pathogenesis of chronic urticaria (CU). Methods Autologous serum skin test (ASST) and skin prick test (SPT) to Df were carried out in 831 patients with CU. The correlation between reactivity to autologous serum and Df was statistically analyzed. Results The positivity rate of ASST and SPT to Df was 51.74% and 64.62%, respectively in the 831 patients. SPT was positive in 56.52% of patients with positive ASST and in 73.86% of those with negative ASST (P ＜ 0.05). In patients with positive ASST, the degree of autologous serum reactivity was negatively correlated with that of reactivity to Df (P ＜ 0.05). Conclusions The skin reactivity to Df and autologous serum plays an important role in the pathogenesis of CU, and the degree of the reactivity to Df and autologous serum is negatively correlated. To conduct ASST and SPT simultaneously in patients with CU may favor the clinical classification and therapy of CU.