The correlation between clinical factors and radiation pneumonitis in advanced stage non-small-cell lung cancer treated with concurrent radiochemotherapy
10.3760/cma.j.issn.1004-4221.2011.01.009
- VernacularTitle:Ⅲb～Ⅳ期非小细胞肺癌同期放化疗临床因素与放射性肺炎相关性研究
- Author:
Lei HAN
;
Bing LU
;
Heyi FU
;
Yinxiang HU
;
Jiaying GAN
;
Huiqin LI
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung/concurrent radiochemotherapy;
Radiotherapy,threedimensional conformal;
Radiotherapy,intensity-modulated late-course accelered hyperfraction;
Radiation paneumonitist
- From:
Chinese Journal of Radiation Oncology
2011;20(1):23-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical factors as predictors of radiation pneumonitis(RP)in advanced stage non-small cell lung cancer(NSCLC)patients treated with concurrent radiochemotherapy when gross tumor volume is 70 Gy. Methods Data of 84 patients with histologically proved NSCLC treated with 3DCRT or IMRT were collected. To evaluate the correlation between clinical parameters and radiation pneumonitis(RP). The clinical parameters were considered: pathological type, therapy agents, age,gender, stage, karnofsky performance status(KPS), smoking status, diabetes, chronic obstructive pulmonary disease(COPD). Results The occurrence of grade 1,2 RP was 63%, 33%, respectively. In univariate analysis, diabetes was significantly associated with RP of ≥ grade 1(x2 =4.03, P = 0.045)and ≥grade 2(x2 = 15.59 ,P =0.000). KPS was significantly associated with RP of ≥grade 1(x2 =3.98 ,P = 0.046)and ≥grade 2(x2 = 5.21, P = 0.023). In logistic multivariate analysis, diabetes was significantly associated with RP of ≥grade 1(x2 =5.50,P =0.019)and ≥grade 2(x2 = 12.92,P =0.000). KPS was significantly associated with RP of ≥ grade 1(x2 = 6.29, P = 0.012)and ≥ grade 2(x2 = 6.61, P =0.010). Conclusion The definite statistical significant risk factors of RP are diabetes and KPS.
