The relationship between plasma homocysteine levels and diabetic peripheral neuropathy
10.3760/cma.j.issn.0578-1426.2011.01.006
- VernacularTitle:血浆同型半胱氨酸与2型糖尿病外周神经病变的相关性
- Author:
Jianbo LI
;
Yuze CHENG
;
Min SHI
;
Hongman ZHANG
;
Qing DAI
;
Yu ZHANG
;
Yanjuan WANG
;
Jiwen CHEN
;
Hongxing WANG
;
Jiawei CHEN
- Publication Type:Journal Article
- Keywords:
Diabetic neuropathies;
Hyperhomocysteinemia;
Risk factors
- From:
Chinese Journal of Internal Medicine
2011;50(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between plasma homocysteine levels and diabetic peripheral neuropathy (DPNP). Methods A crossectional analysis was conducted on 227 patients with type 2 diabetes. Peripheral neuropathy was confirmed using electromyography (EMG). The risk factors possibly associated with diabetic neuropathy or plasma homocysteine levels were analyzed in relation to likelihood of occurrence of DPNP. Results Eighty patients with neuropathy and 147 patients without neuropathy were included. Plasma homocysteine levels were significantly higher in patients with diabetic neuropathy [( 12. 6 ± 3.6 ) μmol/ L] than without diabetic neuropathy [( 8. 2 ± 0. 9 ) μmol/L] ( P ＜0. 001 ), and the relationship remained significant after adjusting for duration of diabetes, glycosylated hemoglobin A1c (HbA1c), age, renal status, serum folate acid and vitamin B12, and metformin [OR 1.15( 1.02-1.28 ) ,P ＜ 0. 05]. In addition, per increase of 4. 0 μmol/L plasma homocysteine was closely related to the occurrence of neuropathy after controlling for per unit increase of other confounding factors [OR 1.17(0. 94-1.33), P ＜ 0. 05]. Conclusions Hyperhomocysteinemia was an independent risk factor for the occourence of diabetic peripheral neuropathy.
