Analysis on clinical features, viral load and viral shedding period of patients with mild or severe H1N1 influenza A virus infection
10.3760/cma.j.issn.1000-6680.2010.12.004
- VernacularTitle:轻型和重型甲型H1N1流行性感冒患者临床特征、病毒载量以及排毒时间分析比较
- Author:
Hong YUAN
;
Guilin YANG
;
Yingxia LIU
;
Weilong LIU
;
Lantian WANG
;
Mutong FANG
;
Guobao LI
;
Yuling JI
;
Liumei XU
;
Puxuan LU
;
Boping ZHOU
- Publication Type:Journal Article
- Keywords:
Influenza A virus,H1N1 subtype;
Influenza,human;
Pneumonia;
Viral load
- From:
Chinese Journal of Infectious Diseases
2010;28(12):722-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze clinical and laboratory features, viral load and viral shedding period of patients with mild or severe H1N1 influenza A infection. Methods Seventy mild cases and 16 severe cases with concurrent pneumonia were included from Shcnzhen area for analysis.Nasopharyngeal-swab specimens of patients were collected and viral load was detected by real-time quantitative polymerase chain reaction (PCR) assay during their hospitalization. The viral load and viral shedding period were compared between patients over 14 years old and less than 14 years old, and between 70 mild cases without pneumonia and 16 severe cases with pneumonia. The statistic analysis was performed using t test and chi square test. Results The most common symptoms and signs of the patients were fever, cough and enlargement of tonsils. However, the severe cases suffered more frequently from cough, dyspnea and high fever compared with the mild cases (x2 = 10. 9 and 14.3, respectively, t=3.65; both P＜0.01 ). The levels of white blood cell (WBC) count and alanine arninotransferase (ALT) of severe patients were both significantly higher than those of mild patients(t= 3.2, 2.4,respectively; both P＜0.05). The chest radiology of the severe cases showed interstitial pneumonia,mostly with ground glass image. The viral load of patients under 14 years was significantly higher than those over 14 years [(4.86± 1.23) lg vs (4. 17±0.89) lg; t=2.3, P＜0.05], and the viral shedding period of patients under 14 years was significantly longer than those over 14 years [(5.33±0. 49) d vs(3. 63±0.28) d; t=3.4, P＜0.01]. The severe patients also displayed significantly higher viral load and prolonged viral shedding period than the mild patients [(6. 36±1. 44) lg vs (4. 35±0.99) lg, t=6.1,P＜0.01; (5.75±1.77) d vs (4. 24±1. 96) d, t=3.2, P＜0.01]. Conclusion Age anddisease severity of patients with H1N1 influenza A infection are significantly associated with viral load and viral shedding period.
