The clinical features of infection in multiple myeloma undergoing autologous hematopoietic stem cell transplantation
10.3760/cma.j.issn.0578-1426.2011.01.013
- VernacularTitle:多发性骨髓瘤患者自体造血干细胞移植后感染的临床特征
- Author:
Juan LI
;
Beihui HUANG
;
Zhenhai ZHOU
;
Dong ZHENG
;
Duorong XU
;
Waiyi ZOU
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Hematopoietic stem cell transplantation;
Infection
- From:
Chinese Journal of Internal Medicine
2011;50(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features of infection in multiple myeloma (MM)undergoing autologous hematopoietic stem cell transplantation (ASCT). Methods Thirty-seven patients with MM undergoing ASCT were retrospectively analyzed for type and time of infection, pathogen, and outcome. Results Fifty-nine cases of infectious complications occurred in 33 patients (89. 2% ) after ASCT, with 34 cases (57.6%) of bacterial infections in 30 patients, 15 cases (25.4%) of fungal infections in 12 patients, 4 cases (6. 8% ) of cytomegalovirus (CMV) infection, 3 cases (5. 1% ) of herpes zoster virus infection and 3 cases (5. 1% ) of HBV reactivation. The proportion of bacterial infection, fungal infection and virus infection were 62. 8%, 28.6% and 8. 6% respectively in the early stage after ASCT, and 50. 0%, 20. 8% and 29. 3% respectively in the median stage. Response to first-line antibiotic therapy was seen in 38 cases (64. 4% ). Infection-related mortality was 8. 1% (3 cases). Conclusions The incidence of infection in MM patients undergoing ASCT is high and they are susceptible to all pathogens. It is important to choose the right antifungal agents as quickly as possible to reduce infection-related mortality.
