Expression of VEGF and its correlation with clinicopathological factors of cervical carcinoma ABSTRACT

VernacularTitle:血管内皮生长因子在宫颈癌组织中的表达及与临床病理因素的关系
Author: Liangliang WANG ; Lihua WANG ; Ling MA ; Beibie WANG ; Jing ZHANG
Publication Type:Journal Article
Keywords: Cervical carcinoma; Hypoxia-inducible factor-1α; Immunohistochemistry
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(24):3315-3316
CountryChina
Language:Chinese
Abstract: Objective This study was designed to examine the expression of VEGF and its correlation with clinicopathological factors of cervical carcinoma. Methods mmunohistochemistry S-P method was used to detect the expression of VEGF in 10 cases of nomal cevical epithelium( NCE), 18 cases of cervical intraepithelial neoplasm (CIN) and 77 cases of early invasive carcinoma of cervix (ICC). Results The positive rate of VEGF protein in NCE,CIN,ICC was 10% (1/10) ,44.4% (8/18) ,74. 0% (57/77), respectively. The defference was significant (P ＜0. 05). Expresson of VEGF was not related with tumor stage, histologic types and stroma infiltration, but related with cell differentiation and intravascular involvement、lymph node metastasis. Conclusion VEGF protein had a positive correlation with cell differentiation and intravascular involvement 、 lymph node metastasis. the expression of VEGF gene result in the occurrence and development of cervical carcinoma by inducing the angiogenesis.