Clinical analysis of 26 patients with invasive fungal infection after allogeneic haemopoietic stem cell transplantation
10.3760/cma.j.issn.1008-6315.2011.01.022
- VernacularTitle:异基因造血干细胞移植侵袭性真菌感染26例临床分析
- Author:
Zhijuan YAO
;
Wenli ZHANG
;
Lihua SUN
;
Beibei PENG
;
Jun WANG
;
Hongyu ZHANG
;
Qingxiang MENG
;
Nailan GUO
- Publication Type:Journal Article
- Keywords:
Allogeneic hematopoietic stem cell transplantation;
Invasive fungal infection;
High-risk factor
- From:
Clinical Medicine of China
2011;27(1):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the high-risk factors,clinical characteristics,therapy and prognosis of invasive fungal infection (IFI)in patients underwent allogeneic haemopoietic stem cell transplantation (AlloHSCT). Methods One hundred patients underwent Allo-HSCT at our department from March 2002 to July 2010 were analyzed retrospectively,among whom 26 patients had invasive fungal infection(IFI). Seven patients had pulmonary IFI before allo-HSCT, 14 patients had pulmonary IFI after allo-HSCT,3 patients had respiratory tract system IFI, and 2 patients had intestinal IFI. We observed the occurrence of Graft-versus-host disease (GVHD) ,cytomegalovirus( CMV )infection, Lymphocyte subsets and chronic basic diseases in patients with IFI. The twenty six cases were divided into two groups: experience therapy group with 12 cases and preemption therapy group with 14 cases. Results Among 26 patients with IFI,20 cases suffered from GVHD,6 cases had CMV infection,19 cases had low cellular immune function simultaneously. 1 case had diabetes,3 patients had pulmonary tuberculosis and 1 case had bronchiectasis as complications. In experience therapy groupe: 8 cases (67%)recovered completely but 1 case(8% )suffered from progressive infection. In preemption therapy groupe:3 cases ( 21% ) recovered completely but 5 cases ( 36% ) suffered from progressive infection. Conclusion Clinician should pay close attention to the patients with high-risk factors of IFI after allo-HSCT.
