Endoscopic implantation of 5-FU slow-release particles for advanced gastroenteric tumor

VernacularTitle:内镜下氟尿嘧啶缓释化疗粒子植入治疗晚期消化道肿瘤的短期疗效观察
Author: Nian FU ; Qing WU ; Xuefeng YANG ; Zhaoxia LIU ; Fei PENG
Publication Type:Journal Article
Keywords: Gastroenteric tumor; 5-FU Slow-release particles
From: Clinical Medicine of China 2011;27(1):75-77
CountryChina
Language:Chinese
Abstract: Objective To investigate the feasibility, safety and short-term efficacy of endoscopic implantation of 5-FU Slow-release Particles for advanced gastroenteric tumor. Methods During the endoscopy procedure,slow-releasing 5-FU agents were implanted densely into the tumors and infiltrated area. Forty-five to sixty pieces of agents ( each piece equivalent to 1.67 mg 5-FU)were injected, which containing an average dose of 100 mg 5-FU. Results A total of 13 advanced gastric cancer patients were enrolled into this study. Significant effects were observed in 3 patients and good effects in 8 patients, but 2 cases with no effects. The total effective rate was 84.62%. The endoscopy examination showed that the size of tumors reduced in various degree at 1 - 2months after the implantation. No hemorrhage or perforation was observed. Parameters of hepatorenal function and routine blood test were stable after implantation. Conclusion Endoscopic implantation of 5-FU Slow-release Particles can relieve the symptoms of patients and limit tumor growth in advanced gastroenteric tumor with no marrow and hepatorenal functional impair.