Progress of bone marrow stromal cells and hematopoietic regulation
10.3760/cma.j.issn.1673-4408.2011.01.025
- VernacularTitle:骨髓基质细胞组成及造血调控作用的研究进展
- Author:
Na DAI
- Publication Type:Journal Article
- Keywords:
Bone marrow;
Stromal cells;
Hematopoiesis;
Regulation
- From:
International Journal of Pediatrics
2011;38(1):71-73
- CountryChina
- Language:Chinese
-
Abstract:
Stromal cells are the important part of the bone marrow microenvironment. They provide a suitable environment for the self-renewal, proliferation and differentiation of the hematopoietic stem cells. Stromal cells include dendritic cells, macrophages, fibroblasts, endothelial cells and adipocytes. They secrete cytokines,extracellular matrix and provide direct cellular contaction to regulate hematopoiesis. Dysfunction of the stromal cells will lead to all kinds of hemopathy and immune system diseases directly.
