The association of fasting insuline and insuline resistance with benign prostatic hyperplasia
10.3760/cma.j.issn.1008-6315.2011.01.005
- VernacularTitle:空腹胰岛素以及胰岛素抵抗与良性前列腺增生症的相关性研究
- Author:
Xianqin MENG
;
Xiaobing QU
;
Wanhong DU
;
Ying LIU
;
Wei LIU
- Publication Type:Journal Article
- Keywords:
Benign prostatic hyperplasia;
Fasting insulin;
Insuline resistance
- From:
Clinical Medicine of China
2011;27(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reveal the effect of fasting insuline(FINS) and insuline resistance(IR) in the process of benign prostatic hyperplasia(BPH). Methods One hundred and seventeen outpatients( ≥60 ys)with BPH from geriatric department were enrolled into the study. The patients were divided into groups according to their FINS and insulin resistance index (HOMA-IR). The indices of BPH, including volume of prostate ( PV ),prostate specific antigen( PSA ), international prostate symptom score (IPSS), course of BPH were analyzed in both groups. Results The PV ( [ 56. 46 ± 26. 88 ] ml vs [ 44. 84 ± 17.66 ] ml, P = 0. 017 ) and the course ( [ 18. 00 ± 6. 91 ] years vs [ 13.93 ± 7. 74 ] years, P = 0. 031 ) were significantly greater in BPH combined hyperinsulinemias(HINS) group than the BPH with normal FINS group;but we found no significant differences in the comparisons of serum PSA level or IPSS between two groups. The PV( [54. 17 ± 25.38 ] ml vs [42. 26 ±14. 15]ml,P =0. 004)and the course([ 16.58 ±7. 65] years vs [13.49 ±7. 59] years,P = 0. 036) were also significantly greater in BPH combined insuline resistance gruop than the insulin sensitivity group, again we found no significant differences in the comparisons of serum PSA level or IPSS between two groups. Conclusion FINS and IR are risk factors of progressed BPH and can promote the progress of BPH.
