Effects of statins and ACEI/ARB treatment on Heme Oxidase-1 expression
10.3760/cma.j.issn.1008-6315.2011.01.028
- VernacularTitle:他汀类药物抗氧化与血红素氧化酶-1蛋白表达的关系
- Author:
Yun ZHANG
;
Duanmin XU
;
Songming CHEN
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Antioxidant treatment;
Heme Oxidase-1
- From:
Clinical Medicine of China
2011;27(1):86-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of statins, angiotensin-converting enzyme inhibitor/adrenergic receptor binder ( ACEI/ARB ) treatment on Heme Oxidase-1 ( HO-1 ) expression in patients with coronary artery disease. Methods HO-1 expression in periphery white blood cells was detected using Western blot before and after 3 months treatment of the above antioxidants in 60 patients who were diagnosed as coronary artery disease by coronary angiography. Results HO-1 expression measured by gray scale peak by western blot was significantly higher after 3 months antioxidant treatment than that before antioxidant treatment( 168. 9 t6. 8vs 112.7 ± 6.3, P = 0.008 ). Conclusion Effects of statins and ACEI/ARB in treating coronary artery disease may be due to its promoting expression of HO-1.
