Expression of MMP-9 and the intervention effect of telmisartan on vascular remodeling of 2K1C Hypertension Rats

VernacularTitle:基质金属蛋白酶-9在高血压大鼠血管重塑中表达及替米沙坦的干预作用
Author: Hong YAN ; Gang SUN ; Qin YAN ; Yancheng DING
Publication Type:Journal Article
Keywords: MMP-9; 2K1 C,Hypertension; Vascular Remodeling; Telmisartan
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(24):3346-3347
CountryChina
Language:Chinese
Abstract: Objective To explore the expression and mechanisms of MMP-9 in vascular remodeling of two-kidney and one-cliped hypertension rats. Methods Male Wistar rats were randomly divided into sham operation group( n = 10), two-kidney and one-clip model (2KIC) group ( n = 10) and telmisartan group ( n = 7 ). Telmisartan group were injected with telmisartan every day. The blood pressure was determined every week. The morphologic change of carotid artery and thoracic aorta was observed with HE stainning 8 weeks after treatment with telmisartan.Arteries was performed to evaluate the expression of MMP-9 with immunohistochemisty. Results The blood pressure,vessel wall,and the expression of MMP-9 in model group were significantly higher than that of control group.Telmisartan nearly normalized arterial pressure and suppressed all these changes. Conclusion MMP-9 was related to vascular remodeling and Telmisartan could regulate vascular remodeling in 2-kidney and 1-cliped hypertension rats by inhibiting the pathway of MMP-9.