Role of nuclear factor-κB in brain ischemic preconditioning
10.3760/cma.j.issn.1673-4165.2010.11.014
- VernacularTitle:核因子-κB在脑缺血预处理中的作用
- Author:
Xin LI
;
Guinan BI
- Publication Type:Journal Article
- Keywords:
NF-κB;
Brain ischemia;
Ischemic preconditioning;
Neuroprotective agents
- From:
International Journal of Cerebrovascular Diseases
2010;18(11):865-871
- CountryChina
- Language:Chinese
-
Abstract:
Brain ischemic conditioning (BIP) can improve the tolerance to ischemic injury in the brain. Nuclear factor-κB (NF-κB) is an important transcriptional regulatory factor.It presents in all types of cells in the nerous system. Studies have suggested that BIP may exert neuroprotective effects by mediating NF-κB through a series of cascade reactions. This may provide a new therapeutic strategy for BIP in the prevention and treatment of ischemic cerebrovascular disease in clinical practice.
