Effects of different neurolytic drugs on function of motor nerve fibers of rat sciatic nerve
10.3760/cma.j.issn.0254-1416.2010.10.021
- VernacularTitle:不同神经毁损药对大鼠坐骨神经运动神经功能的影响
- Author:
Chunfu WAN
;
Xiaoli LIU
;
Zhihua LI
;
Jinge YUAN
;
Shuping CHANG
- Publication Type:Journal Article
- Keywords:
Denervation;
Sciatic nerve;
Neural conduction;
Motor neurons
- From:
Chinese Journal of Anesthesiology
2010;30(10):1224-1226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change in the function of the motor nerve fibers of the sciatic nerve of rat following injection of different neurolytic drugs. Methods Thirty-five SD rats weighing 350-380 g were randomly divided into 7 groups ( n = 5 each): group C received normal saline; group Ad adriamycin 5 mg/ml;group Aa anhydrous alcohol; group Pg1 8% phenol-glycerol; group Pg2 10% phenol-glycerol; group Pg3 12% phenol-glycerol and group Ci cidomycin 4000 U/ml. 0.2 ml of the different neurolytic drugs was injected at the points where the branches of the sciatic nerve entering semi-membranous and adductor magnus muscles. The action potential and conduction velocity of motor and sensory nerve fibers were measured at 21 d after injection. Results The conduction velocity of sensory nerve fibers was 0 in each group. The conduction velocity and action potential of the motor nerve fibers were significantly decreased in group Ad, Aa, Pg1, Pg2, Pg3 and Ci as compared with group C (the control group). The action potential and the conduction velocity were significantly higher in group Ad than in other neurolytic drug groups. The potential and the conduction velocity were the lowest in group Aa and Pg3.The conduction velocity in group Pg1, Pg2, Ci was comparable. Conclusion 5% adriamycin seems to be a better neurolytic drug with less interference with function of motor never fibers.
